4-Acetoxy-N, N-dimethyltryptamine (also known as 4-AcO-DMT, 4-Acetoxy-DMT, O-Acetylpsilocin, and psilacetin) is a novel psychedelic substance of the tryptamine class. It is chemically similar to psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). It belongs to a group known as the substituted tryptamines which act by stimulating serotonin receptorsin the brain.
The synthesis of 4-AcO-DMT was first reported in 1963 by Albert Hofmann and Franz Troxler. However, its properties were not examined and no further studies were carried out.
A 1999 paper by David E. Nichols suggested it as a useful alternative to psilocybin for pharmacological research. Reports of human use began to surface following its appearance on the online research chemical market in the 2010s.
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User reports indicate that the subjective effects of 4-AcO-DMT are near identical to those of psilocybin mushrooms. Like psilocybin, this product is theorize to act as a prodrug to psilocin, which may account for this similarity. Characteristic effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss.
4-AcO-DMT’s classical psychedelic effects and favorable tolerability profile have led it to become popular among novel psychoactive substance users, particularly those seeking mystical-like or entheogenic experiences.
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Very little data exists on the pharmacology, metabolism, and toxicity of 4-AcO-DMT. Like other psychedelics, it is assume to be non-toxic and non-addictive (although there is no evidence to support this). It is highly advise to use harm reduction practices if using this substance.
The toxicity and long-term health effects of this product have not been studied and the exact toxic dose is unknown. This is because the product is a research chemical with a very short history of human usage.
It is assume to have a similar safety profile as psilocybin mushrooms due to their similar chemical structures, although there is currently no data to support this.